Location, Size, and Population
Populations ebb and flow due to a multitude of external factors. Advances in sanitation, medicine, and agriculture can spur dramatic population growth, while war, economic downturn, or plague can devastate it. A megacity has at least 10 million residents. Megaplexes formed of multiple megacities might have populations averaging 50 million or more. A multi-planetary alliance might have billions or more.
Population size is only part of the equation. Figuring out the ancestry ratios of that population and brainstorming how the members of various ancestries interact can often lead to interesting story ideas, or at least give you some jumping-off points when dreaming up how the settlement was founded and its later history.