Composition of Space
Celestial Spheres: The ancient Greeks posited that planets, stars, and more were embedded like jewels within celestial orbs of quintessence nested within one another. Perhaps celestial bodies in your campaign are really massive aeon stones, or something else unique to your setting.
Endless Sky: What if the blue sky overhead extended outward forever? One need only fly high enough and far enough to reach another world, using environmental protections to defend against the frigid cold. In such a campaign, space might not carry the hazards of radiation and breathlessness, but it might be more like a vast sea where ships and people flow with the currents and explore the depths.
Vacuum: In conventional astronomy, outer space is an immense void existing in a near-perfect vacuum. The immeasurable expanse of space is home to everything in the Universe and requires starships to both navigate and survive. You might incorporate hard sci-fi details to make adventures in outer space feel more believable and perilous.